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Explore our premium cosmetic-grade actives designed for advanced skin soothing formulations
Cosmetic Ingredient 99% Pure AHK-CU Copper for Skin Soothing & Hair Growth
Factory Supply Bulk Astaxanthin 1% 2% 5% Pure Astaxanthin Powder for Skin Soothing
Pure Azelaic Acid Powder — Pharmaceutical Grade for Skin Soothing & Brightening
Natural Botanical Extract Series for Skin Soothing & Anti-Inflammation
Pure Azelaic Acid (nonanedioic acid, C₉H₁₆O₄) is a naturally occurring dicarboxylic acid found in grains such as wheat, rye, and barley. In its refined, pharmaceutical-grade form, it has become one of the most scientifically validated active ingredients in modern dermatology and cosmetic science.
At concentrations of 15–20%, azelaic acid is prescribed for acne vulgaris and rosacea. At lower concentrations (5–10%), it functions as a powerhouse skin-soothing and brightening agent in over-the-counter cosmetic formulations — reducing redness, calming inflammation, inhibiting melanin synthesis, and gently exfoliating the skin surface.
Shaanxi Qiyuan Kangjian Biotechnology supplies 99%+ purity azelaic acid manufactured under GMP standards, meeting the stringent requirements of pharmaceutical, nutraceutical, and high-performance cosmetic applications worldwide.
Backed by decades of clinical research, pure azelaic acid delivers a multi-mechanism approach to calming, clarifying, and renewing sensitive and troubled skin.
Azelaic acid inhibits the production of reactive oxygen species (ROS) and down-regulates pro-inflammatory cytokines, directly reducing redness and swelling associated with rosacea, acne, and sensitive skin conditions.
By competitively inhibiting tyrosinase, the key enzyme in melanin synthesis, pure azelaic acid reduces hyperpigmentation, post-inflammatory dark spots, and melasma — delivering a visibly more even skin tone over 8–12 weeks of consistent use.
Azelaic acid normalizes keratinization within the follicular duct, preventing the formation of comedones (blackheads and whiteheads) and reducing pore-clogging without the irritation associated with retinoids or strong AHAs.
Clinically proven to inhibit Cutibacterium acnes (formerly P. acnes) growth without contributing to antibiotic resistance, making it a preferred long-term solution for acne management in both prescription and cosmetic formulations.
Unlike many actives, azelaic acid is safe for use during pregnancy (Category B), suitable for all Fitzpatrick skin types, and well-tolerated by even the most reactive skin — making it a universal soothing ingredient for global cosmetic markets.
Azelaic acid works synergistically with Vitamin C, niacinamide, and antioxidant-rich plant extracts to neutralize free radicals, protect the skin barrier, and enhance overall skin luminosity — a key selling point for premium anti-aging and brightening SKUs.
At Shaanxi Qiyuan Kangjian Biotechnology, our pure azelaic acid achieves ≥99% purity verified by HPLC analysis. Every batch undergoes rigorous QC testing — including heavy metal screening, microbial testing, and residual solvent analysis — and is validated by internationally accredited third-party laboratories including SGS, Eurofins, and Pony Testing. This ensures our azelaic acid meets USP, EP, and JP pharmacopoeial standards, qualifying for use in both prescription dermatological products and premium cosmetic formulations globally.
The azelaic acid market is experiencing robust growth driven by rising consumer awareness of skin health, the clean beauty movement, and increasing dermatologist recommendations worldwide.
The global azelaic acid market was valued at approximately USD 620 million in 2023 and is projected to exceed USD 1.1 billion by 2030, growing at a CAGR of 8.4%. This growth is fueled by rising incidences of acne and rosacea globally, the booming K-beauty and clean skincare movements, and a shift toward multi-functional active ingredients that deliver both therapeutic and cosmetic benefits.
Azelaic acid has received approval from the FDA (USA), EMA (Europe), and regulatory bodies across Asia-Pacific for both OTC cosmetic use and prescription dermatological applications. Increasing approvals in emerging markets — including Southeast Asia, the Middle East, and Latin America — are opening new distribution channels for bulk API and cosmetic ingredient suppliers like Qiyuan Kangjian.
Consumer demand for fragrance-free, non-irritating, and clinically validated skincare has surged post-pandemic. Azelaic acid's excellent safety profile — no photosensitivity, no bleaching of normally pigmented skin, and suitability for pregnancy — positions it as a cornerstone ingredient in the clean beauty and sensitive skin segments, which collectively represent over 35% of the global skincare market.
Traditional chemical synthesis routes for azelaic acid are being complemented by emerging biotechnological fermentation methods using oleic acid-metabolizing microorganisms. These bio-based production pathways offer lower carbon footprints and higher purity profiles, aligning with ESG (Environmental, Social, Governance) commitments increasingly required by global cosmetic and pharmaceutical brands. Qiyuan Kangjian is actively investing in next-generation bioprocessing capabilities.
Global cosmetic brands — from indie startups to multinational corporations — are increasingly outsourcing active ingredient formulation to specialized suppliers. The demand for OEM-grade pure azelaic acid with custom specifications (particle size, solubility enhancement, microencapsulation) is growing rapidly, particularly from markets in North America, Europe, and the UAE. Qiyuan Kangjian's OEM customization services are precisely positioned to capture this demand.
Formulators are increasingly combining azelaic acid with complementary actives — niacinamide (for synergistic brightening), tranexamic acid (for melasma), retinol (for anti-aging), and hyaluronic acid (for barrier support). This trend toward multi-active "cocktail" formulations is driving demand for high-purity, highly compatible azelaic acid grades that maintain stability across diverse formulation matrices and pH ranges (4.0–6.5).
Pure azelaic acid's versatility spans pharmaceutical, cosmetic, and emerging biotechnology sectors — each with distinct formulation requirements and market opportunities.
15–20% azelaic acid gels and creams (e.g., Finacea®, Skinoren®) are FDA/EMA-approved for moderate acne and rosacea. High-purity API-grade supply is critical for pharmaceutical manufacturers requiring USP/EP compliance, certificate of analysis, and full batch traceability.
At 5–10% concentrations, pure azelaic acid is the hero ingredient in bestselling brightening serums, rosacea-calming moisturizers, and anti-blemish treatments. Its stability in aqueous and silicone-based matrices makes it ideal for both water-phase and anhydrous formulations.
Advanced cosmetic technology is leveraging microencapsulated azelaic acid for controlled release, enhanced skin penetration, and improved consumer sensory experience. Nano-emulsion and liposomal delivery formats are entering clinical trials for next-generation prescription products.
As bio-fermentation-derived azelaic acid becomes commercially viable, natural and certified organic skincare brands can now incorporate this powerful soothing ingredient while maintaining clean-label claims. This opens a premium market segment valued at over USD 180 billion globally.
Medical aesthetic clinics are incorporating azelaic acid into professional peel protocols, post-procedure soothing regimens, and combination treatments with laser therapy or chemical peels. The clinical channel represents a high-value, fast-growing distribution pathway for pharmaceutical-grade azelaic acid.
The rise of direct-to-consumer (DTC) skincare brands on platforms like Amazon, Tmall, and Shopify has created massive demand for small-batch, high-purity azelaic acid with fast turnaround. OEM and white-label services from suppliers like Qiyuan Kangjian enable rapid product development cycles for agile indie brands.
Shaanxi Qiyuan Kangjian Biotechnology Co., Ltd. — Your trusted partner for pharmaceutical-grade azelaic acid and premium bioactive ingredients
Shaanxi Qiyuan Kangjian Biotechnology Co., Ltd. is located in Xi'an, Shaanxi Province, China, and specializes in supplying peptides, food additives, nutritional supplements, traditional Chinese medicine (TCM) extracts, plant extracts, and natural active ingredients.
Qiyuan Kangjian Biotech Co., Ltd.
Our team members are familiar with the trade policies and compliance requirements of various countries, always prioritizing customer needs, strictly controlling quality, and responding efficiently. From order negotiation to after-sales follow-up, dedicated personnel handle the entire process, using professionalism and integrity to build bridges for cross-border cooperation and help partners explore global business opportunities!
Contact UsState-of-the-art GMP manufacturing infrastructure ensuring pharmaceutical-grade azelaic acid production at scale
The company has two major production bases in Weinan and Xianyang. Weinan Shenhekang Bioengineering Co., Ltd., established in 2022, boasts a 6,000-square-meter GMP-compliant production workshop.
This base is equipped with multi-functional plant extraction equipment for extraction, separation, concentration, and drying, as well as a complete production line, with an annual processing capacity of nearly 3,000 tons of various traditional Chinese medicinal materials and the production of 300 tons of raw materials.
The company has an independent R&D team and a standardized laboratory equipped with advanced testing instruments, including thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC), ultraviolet-visible spectrophotometer (UV), and gas chromatography (GC), implementing strict technical control over the entire production process from raw material collection to finished product delivery.
The company has also established in-depth strategic partnerships with internationally renowned third-party testing organizations such as SGS, Eurofins, Layan Testing, and Pony Testing to ensure rigorous product quality management.
Serving the global pharmaceutical, health product, and cosmetics industries with integrity, quality, and comprehensive support
Adhering to the corporate philosophy of "rooted in our initial vision, empowered by biotechnology; upholding integrity and taking steady action to benefit the people" and the belief that "quality is our lifeline," the company leverages its group operating model and global distribution network to serve clients in the pharmaceutical, health product, and cosmetics industries.
Its products have gained global recognition and are exported to over 36 countries in Asia, the Middle East, Europe, North America, Latin America, and Africa. With independent import and export licenses, the company has established strong partnerships with international express companies and air and sea freight forwarders to provide timely and professional services. The company also offers a comprehensive sales and service system, including OEM customization services and tailored solutions for clients with new product ideas but lacking laboratory equipment and human resources.
Discover our full range of premium cosmetic actives and pharmaceutical-grade ingredients for skin soothing formulations
99% Pure AHK-CU Copper Peptide for Skin Soothing & Repair
Bulk Astaxanthin 1%–5% Powder for Skin Soothing & Anti-Aging
Pure Azelaic Acid 99% — Pharmaceutical Grade for Skin Soothing
Natural Plant Extract Series for Skin Soothing & Brightening
Cosmetic Peptide Complex for Skin Soothing & Collagen Synthesis
Traditional Chinese Medicine Extract for Skin Soothing & Calming
Pharmaceutical-Grade Niacinamide for Skin Soothing & Pore Minimizing
Nutritional Supplement Active for Skin Soothing & Barrier Repair