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Precision-formulated grades of Sodium Hyaluronate designed to address acne, reduce inflammation, and restore skin barrier function.
Deep-penetrating ultra-low molecular weight HA that targets acne inflammation at the dermal level, accelerating healing and reducing redness.
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Low molecular weight grade offering superior skin absorption and anti-inflammatory benefits, ideal for acne serum and spot treatment formulations.
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Balanced medium molecular weight HA that hydrates acne-prone skin without clogging pores, supporting a healthy and clear complexion.
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High molecular weight HA forming a protective moisture film on the skin surface, reducing transepidermal water loss and calming acne irritation.
Learn More →Sodium Hyaluronate (SH) is the sodium salt form of Hyaluronic Acid — a naturally occurring polysaccharide found abundantly in human connective tissues and skin. With a smaller molecular size than native Hyaluronic Acid, Sodium Hyaluronate demonstrates superior water solubility and skin penetration, making it an exceptional active ingredient in modern acne treatment formulations.
Acne is not merely a surface-level concern. It involves chronic inflammation, disrupted skin microbiome, impaired barrier function, and excessive sebum production. Sodium Hyaluronate addresses multiple dimensions of this complex condition simultaneously — making it a highly versatile and scientifically validated ingredient in both pharmaceutical and cosmetic acne therapies.
Clinical research confirms that Sodium Hyaluronate reduces pro-inflammatory cytokines in acne lesions, accelerates post-acne wound healing, and restores epidermal barrier integrity — all without comedogenic risk.
Unlike heavy oils or occlusive emollients that can worsen breakouts, Sodium Hyaluronate is inherently non -comedogenic, lightweight, and compatible with all skin types — including oily and combination skin prone to acne.
Multi-dimensional action that targets the root causes of acne while supporting long-term skin health.
Sodium Hyaluronate binds up to 1,000× its weight in water, delivering intense hydration to acne-prone skin without occluding follicles or triggering new breakouts.
Low and ultra-low molecular weight grades penetrate the dermis to suppress NF-κB signaling and reduce interleukin-mediated inflammation in active acne lesions.
By stimulating keratinocyte proliferation and fibroblast migration, Sodium Hyaluronate speeds up post-acne healing and minimizes the risk of scarring and hyperpigmentation.
Restores compromised epidermal barrier function in acne-damaged skin, reducing transepidermal water loss (TEWL) and improving overall skin resilience.
Adequate skin hydration provided by SH helps signal sebaceous glands to reduce excess oil production — addressing a core trigger of acne formation.
Sodium Hyaluronate supports a balanced skin microbiome environment, helping to inhibit the overgrowth of Cutibacterium acnes without disrupting beneficial flora.
The global market for Hyaluronic Acid-based skincare is experiencing unprecedented growth, driven by rising acne prevalence and consumer demand for science-backed solutions.
From pharmaceutical-grade APIs to cosmeceutical actives — the industrial ecosystem around Sodium Hyaluronate is rapidly evolving.
The global acne treatment market, valued at over USD 5.6 billion in 2023, is witnessing a significant shift toward biologically derived, non-antibiotic ingredients. Sodium Hyaluronate has emerged as a frontrunner in this transition, replacing harsher actives like benzoyl peroxide in next-generation formulations. Major cosmetic conglomerates in Europe, North America, and Asia-Pacific are actively incorporating high-purity Sodium Hyaluronate into their acne product pipelines.
China remains the world's leading producer of fermentation-derived Sodium Hyaluronate, accounting for over 80% of global supply. Advanced biotechnology companies like Shaanxi Qiyuan Kangjian Biotechnology Co., Ltd. are at the forefront of this production, leveraging GMP-certified manufacturing facilities and rigorous quality control protocols to supply pharmaceutical, nutraceutical, and cosmetic-grade SH to global buyers.
Modern industrial production of Sodium Hyaluronate relies primarily on microbial fermentation using Streptococcus zooepidemicus or recombinant Bacillus subtilis strains. This biotechnological approach has replaced animal-derived extraction (from rooster combs), offering superior purity, scalability, and vegan compliance. The fermentation process yields high-molecular-weight HA that can then be enzymatically or chemically depolymerized to produce low, ultra-low, and oligomeric grades — each with distinct skin penetration depths and therapeutic profiles suited for acne treatment.
Industrial-scale production demands strict control of fermentation parameters, downstream purification via ultrafiltration and ion-exchange chromatography, and precise molecular weight characterization using GPC (Gel Permeation Chromatography). Quality benchmarks such as heavy metal limits, endotoxin levels, and microbial counts are rigorously enforced to meet pharmacopeial standards (USP, EP, JP).
Qiyuan Kangjian Biotech operates a 6,000 m² GMP-compliant facility equipped with advanced fermentation, extraction, and analytical infrastructure — delivering Sodium Hyaluronate that meets the highest international pharmaceutical and cosmetic standards for acne treatment applications.
Globally, Sodium Hyaluronate is classified as GRAS (Generally Recognized As Safe) by the US FDA for topical and oral use. The EU Cosmetics Regulation (EC No 1223/2009) permits its use without restriction in cosmetic formulations. In China, it is listed in the NMPA Cosmetic Ingredient Inventory and approved for use in Class II medical devices for wound care — which directly encompasses post-acne scar treatment products. These favorable regulatory frameworks are accelerating product launches and market penetration across all major geographies.
Innovation at the intersection of biotechnology, dermatology, and consumer science is reshaping how Sodium Hyaluronate is applied in acne care.
Dissolvable microneedle patches loaded with cross-linked Sodium Hyaluronate are gaining traction as a targeted acne spot treatment. These patches deliver SH directly into the dermis, enabling localized anti-inflammatory action and accelerated healing of cystic acne lesions — a technology now entering mass-market commercialization in South Korea, Japan, and the US.
Brands are leveraging AI skin analysis platforms to prescribe personalized Sodium Hyaluronate concentrations and molecular weight combinations based on individual acne severity, skin type, and microbiome profile. This data-driven approach is moving SH from a generic ingredient to a precision-medicine-grade active in customized acne therapeutics.
Consumer demand for vegan, cruelty-free acne products is accelerating the adoption of bio-fermentation-derived Sodium Hyaluronate. Brands emphasizing clean beauty and sustainability are reformulating their acne lines with plant-fermented SH, supported by transparent supply chain certifications — a trend strongly aligned with Gen Z purchasing behavior.
Emerging clinical evidence supports the use of oral Sodium Hyaluronate supplementation to reduce systemic inflammation associated with moderate-to-severe acne. Nutraceutical brands are launching HA capsules and powders targeting gut-skin axis modulation — a novel application that positions SH as a holistic acne management ingredient beyond topical use.
Multi-active acne formulations combining Sodium Hyaluronate with niacinamide (pore-minimizing, sebum-regulating) and Centella Asiatica (scar-healing, anti-inflammatory) are dominating new product launches in Asia-Pacific. These synergy complexes outperform single-active products in clinical efficacy trials and command premium retail positioning.
Nanotechnology-enabled encapsulation of Sodium Hyaluronate in liposomes or polymeric nanoparticles allows for controlled, sustained release of the active into acne-affected skin. This technology maximizes therapeutic duration, reduces dosing frequency, and improves patient compliance — representing the next frontier in pharmaceutical-grade acne treatment product development.
From daily skincare to clinical dermatology — Sodium Hyaluronate integrates seamlessly across the full acne treatment spectrum.
The highest-volume application segment. Ultra-low and low molecular weight Sodium Hyaluronate (5–100 kDa) is incorporated at 0.1–2% concentrations in water-based serums targeting active acne. These formulations deliver anti-inflammatory hydration directly to inflamed follicles, reducing papule and pustule severity while maintaining skin comfort during concurrent use of drying acne actives like salicylic acid or retinoids.
Medium to high molecular weight SH (500–1800 kDa) is widely used in post-acne repair creams and masks. Its film-forming and moisture-retaining properties create an optimal wound-healing microenvironment, reducing the risk of post-inflammatory hyperpigmentation (PIH) and atrophic scarring. Dermatologist-recommended post-procedure recovery products for laser acne treatments routinely feature SH as a key regenerative active.
In pharmaceutical applications, Sodium Hyaluronate serves as both an active ingredient and a drug delivery vehicle. Its mucoadhesive and viscoelastic properties enable it to carry acne antibiotics (clindamycin, erythromycin) or retinoids (tretinoin) into follicular channels with enhanced bioavailability. HA-based hydrogel matrices are being investigated as sustained-release vehicles for next-generation prescription acne therapies.
In clinical dermatology settings, injectable-grade Sodium Hyaluronate is used for intradermal treatment of atrophic acne scars (rolling scars, boxcar scars). Mesotherapy protocols using diluted SH injections stimulate collagen synthesis and restore dermal volume in scar depressions. This application bridges the gap between cosmetic and medical use, representing a rapidly growing segment in aesthetic medicine globally.
B2B supply of high-purity Sodium Hyaluronate to contract manufacturers and cosmetic brands represents a major commercial application. Companies like Qiyuan Kangjian Biotech supply pharmaceutical and cosmetic-grade SH with full documentation (COA, MSDS, TDS, stability data) to support OEM acne product development. Custom molecular weight specifications, particle sizes, and packaging formats are available to meet diverse formulation requirements worldwide.
Your trusted source for pharmaceutical and cosmetic-grade Sodium Hyaluronate for acne treatment formulations.
Shaanxi Qiyuan Kangjian Biotechnology Co., Ltd. is located in Xi'an, Shaanxi Province, China, and specializes in supplying peptides, food additives, nutritional supplements, traditional Chinese medicine (TCM) extracts, plant extracts, and natural active ingredients.
With a GMP-certified production base, an independent R&D team, and a global distribution network spanning 36+ countries, we are committed to delivering the highest-quality Sodium Hyaluronate and biotechnology ingredients to partners in the pharmaceutical, health product, and cosmetics industries worldwide.
Qiyuan Kangjian Biotech Co., Ltd.
Our team members are familiar with the trade policies and compliance requirements of various countries, always prioritizing customer needs, strictly controlling quality, and responding efficiently. From order negotiation to after-sales follow-up, dedicated personnel handle the entire process, using professionalism and integrity to build bridges for cross-border cooperation and help partners explore global business opportunities!
Contact UsState-of-the-art GMP manufacturing infrastructure ensuring the highest purity Sodium Hyaluronate for acne treatment applications.
The company has two major production bases in Weinan and Xianyang. Weinan Shenhekang Bioengineering Co., Ltd., established in 2022, boasts a 6,000-square-meter GMP-compliant production workshop.
Delivering premium Sodium Hyaluronate for acne treatment to partners across 36+ countries with full-service support.
Adhering to the corporate philosophy of "rooted in our initial vision, empowered by biotechnology; upholding integrity and taking steady action to benefit the people" and the belief that "quality is our lifeline," the company leverages its group operating model and global distribution network to serve clients in the pharmaceutical, health product, and cosmetics industries.
Its products have gained global recognition and are exported to over 36 countries in Asia, the Middle East, Europe, North America, Latin America, and Africa. With independent import and export licenses, the company has established strong partnerships with international express companies and air and sea freight forwarders to provide timely and professional services. The company also offers a comprehensive sales and service system, including OEM customization services and tailored solutions for clients with new product ideas but lacking laboratory equipment and human resources.
We go beyond ingredient supply — we are your long-term partner in acne treatment product innovation and quality assurance.
Our 6,000 m² production facility operates under strict GMP standards, ensuring every batch of Sodium Hyaluronate for acne treatment meets pharmaceutical-grade purity and consistency requirements.
We provide complete documentation packages including COA, MSDS, TDS, HPLC reports, heavy metal testing, and microbial analysis — supporting smooth regulatory submissions in all major markets.
From ultra-low (5 kDa) to high molecular weight (1800 kDa), we offer tailored Sodium Hyaluronate specifications to match your exact acne formulation requirements and delivery system.
With products exported to 36+ countries and established partnerships with SGS, Eurofins, and other international testing bodies, we ensure seamless cross-border trade and compliance.
From concept to finished acne product, our OEM team provides end-to-end formulation support, packaging design, and regulatory guidance — ideal for brands without in-house R&D capabilities.
Our dedicated trade team ensures rapid quotation, efficient order processing, and reliable logistics via air, sea, and express freight — minimizing lead times for your acne product launches.
Explore our full range of Sodium Hyaluronate grades and related bioactive ingredients for comprehensive acne care formulations.
Ultra-low MW grade optimized for water-based acne serum formulations with maximum skin penetration depth.
Learn More →Concentrated low MW SH for targeted acne spot treatment gels with rapid anti-inflammatory action on active lesions.
Learn More →Medium MW grade designed for post-acne scar repair creams, supporting collagen synthesis and skin texture restoration.
Learn More →High MW film-forming SH for non-comedogenic acne moisturizers that hydrate without triggering new breakouts.
Learn More →Dissolvable microneedle-grade SH engineered for transdermal acne patch applications with controlled release profiles.
Learn More →Cross-linkable SH grade for hydrogel sheet masks targeting inflamed acne-prone skin with soothing, cooling hydration.
Learn More →Pharmaceutical-grade SH matrix for drug delivery systems carrying acne actives (retinoids, antibiotics) into follicular channels.
Learn More →Food-grade Sodium Hyaluronate for oral nutraceutical formulations targeting systemic inflammation linked to acne pathogenesis.
Learn More →Partner with Qiyuan Kangjian Biotech — your trusted GMP-certified supplier of high-purity Sodium Hyaluronate grades for pharmaceutical, cosmeceutical, and OEM acne treatment product development.
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